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It has been believed that T lymphocytes of the immune system learn tolerance (avoiding attack) on self-tissues by confronting their native proteins in two areas:
- the thymus gland, and
- peripheral tissues.
However researchers, at Joslin Diabetes Center, Harvard Medical School, and other institutions, have recently shown that T cells confront the peripheral self-proteins in the thymus gland itself.
These "shadow proteins" result from the expression of numerous genes associated with the liver, brain, pancreas and other organs.
Visit the Joslin Diabetes Center for the full article: Shadow Proteins in Thymus May Explain How Immune System Gets to Know Its Own Body
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